ENCRYPT will develop a scalable, practical, adaptable privacy-preserving framework, allowing researchers and developers to process data stored in federated cross-border data spaces in a GDPR-compliant way. Within this framework, a recommendation engine for citizens and end-users will be developed, providing them with personalised suggestions on privacy preserving technologies depending on the sensitivity of data and the accepted trade-off between the degree of security and the overall system performance. The ENCRYPT framework will be designed taking into consideration the needs and preferences of relevant actors, and will be validated in a comprehensive, 3-phase validation campaign, comprising i) in-lab validation tests, ii) use cases provided by consortium partners in three sectors, namely the health sector, the cybersecurity sector, and the finance sector, that include cross-border processing of data, and iii) external use cases including privacy preserving computations on federated medical datasets.